Job Description

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Oxford BioTherapeutics provided pay range

This range is provided by Oxford BioTherapeutics. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$130,000.00/yr - $160,000.00/yr

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Highly experienced organisation capability consultant and HR interim

About Oxford BioTherapeutics

Oxford BioTherapeutics (OBT) is a clinical stage oncology company with a pipeline of immuno-oncology and antibody-drug conjugate-based therapies. OBT's IO discovery process provides unique insight into the cancer-immune cell synapse and has identified several novel IO candidates for cancer therapy. Discovery of novel tumor antigens and immune cell surface proteins at OBT is performed using the proprietary Oxford Genome Anatomy Project (OGAP) database. OBT currently has one ADC in phase 1b clinical trials in collaboration with Menarini. OBT is a dynamic, growing, international biotechnology company based in Oxford, UK, and San Jose, CA.

For further information, please see

Purpose of the Role

We are seeking a Senior Scientist experienced in ADC and Translational Science to join our team. This person will contribute directly to OBT’s Oncology ADC pipeline and drive innovation with cancer biologists, immunologists, and protein and antibody discovery scientists to develop first-in-class ADC therapies. They must be a team player, strategic thinker, and effective communicator to accomplish the company’s goals in the fast-paced and dynamic industry environment.

The Antibody drug conjugate (ADC) & Translational Science team is at the forefront of developing and delivering novel targeted therapies for the unmet needs to transform the lives of cancer patients. We identify, validate, and advance the discovery of new ADCs through comprehensive biological evaluations of tumor-associated antigens, their targeting antibodies, and linker payloads, as well as vigorous preclinical studies. As we drive toward the next generation of therapeutics, we seek an energetic, highly motivated, and interactively proficient scientist to perform hands-on experiments to advance projects and/or development decisions.

Essential Duties and Responsibilities:

• Design and execute in vitro and ex vivo experiments independently to identify and characterize novel tumor-associated antigens and evaluate ADC payloads that inform and enable project progression
• Utilize diverse molecular and cell-based techniques including antibody internalization rate analysis, antigen recycle rate analysis, antigen density analysis, various effector-dependent and independent cytotoxicity assays in high throughput and real time manners, ELISA, multiplex cytokine assays, cytokine immunoassays, quantitative multi-colored flow cytometry analysis (FlowJo), GraphPad Prism, CyTOF, gene set enrichment analysis, bioanalytical pharmacokinetic (PK) and pharmacodynamic (PD) assays
• Expand the capabilities of ADC and translational science group by implementing new techniques and cutting-edge technologies
• Provide expert insight into cancer biology and stay up to date with relevant literature
• Collaborate across teams and require presenting research results at internal and external meetings
• Cultivate a culture of scientific excellence, urgency, critical thinking, and continuous learning
• Independently devise, execute, and analyze hypothesis-driven translational research experiments to identify PD biomarkers, mechanisms of sensitivity and resistance and test novel drug-combinations to further advance the OBT ADC pipeline
• Lead programs by executing lead optimization strategies and driving discovery goals
• Prepare patent applications and publish impactful research
• Supervise, mentor and train less experienced employees

Please note the roles and responsibilities for the position include but are not limited to the above.

Knowledge, Experience, and Skills:

• PhD in cancer biology, immuno-oncology, pharmacology, pharmaceutical sciences, or related discipline. Master’s degree with 8-10+ years of experience or bachelor’s degree with 10-12+ years of experience in the biopharmaceutical industry
• Post-doctoral training (4+ years) or MD in oncology or related field in academia or pharma industry
• Self-motivated with a strong desire to uncover novel biology and develop new therapeutics
• Experience with primary human cellular/tissue-based assays to guide/inform indication selection, biomarker discovery and mechanism-of-action
• Experience with quantitative FACS using multiple color-labeled markers by design
• Deep-understanding statistical design and analysis (i.e., GraphPad Prism) for preclinical experiments
• Ability to identify and plan critical experiments aligned with team objectives
• Strong problem-solving skills to address complex challenges with innovative and effective approaches
• Experience working in matrix teams to deliver defined objectives
• Highly effective interpersonal skills and collaborative mindset with the ability to communicate with diverse stakeholders and facilitate critical decision making
• Strong written and verbal communication skills to present to both internal and external collaborators

Behaviors:

• Highly self-motivated
• Adopts a resilient and proactive approach
• Team oriented
• Supportive
• Flexibility and agile
• Readiness to learn new methods

One of our top priorities is to maintain the health and wellbeing of our employees and their families. To achieve this goal, we offer comprehensive benefits.

Benefits Offered:

• Medical, dental and vision insurance
• FSA (Flexible Spending Account)
• STD, LTD, Basic Life, Supplemental Life and AD&D Insurance
• 401(k) Plan
• Up to 120 hours of Paid Time Off in your first year (increasing with tenure)
• 5 sick days per year
• 11 paid holidays
• Employee Referral Bonus Program
• Team building events and activities

OBT is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status, and veteran status. All qualified applicants will receive consideration for employment.

Why Join Us

We promote a culture of innovation, responsibility, and commitment to our goals and objectives. Together, we believe, we can pool our resources and our uniqueness to develop novel, robust cures for one of the most challenging health conditions today. We recognize that our team is only as good as the people in it. Our people have used the words friendly, collaborative, and hard working to describe the culture here at OBT. This is why, while we strive to ensure that we hire only the best people. We also strive to provide a working environment that is based on cooperation, innovation, and mutual respect.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research and Analyst

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Medical insurance

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401(k)

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